Edinger, Matthias (2016) Driving allotolerance: CAR-expressing Tregs for tolerance induction in organ and stem cell transplantation. JOURNAL OF CLINICAL INVESTIGATION, 126 (4). pp. 1248-1250. ISSN 0021-9738, 1558-8238
Full text not available from this repository. (Request a copy)Abstract
Regulatory T cells (Tregs) modulate the function of a variety of immune cells and are critical for maintaining self-tolerance and preventing the development of autoimmune disease. Due to their ability to suppress effector T cells, Tregs have been increasingly explored for clinical use to suppress alloresponses. While this approach has been promising in preclinical models and early clinical trials, widespread clinical use of Tregs has been limited by the low number of these cells in the periphery and the unknown frequency of allo-responsive Tregs. In this issue of the JCI, MacDonald and colleagues transduced human Tregs with a chimeric antigen receptor (CAR) that targets the HLA class I molecule A2. These CAR expressing T cells were readily activated via CAR stimulation and exerted potent immunosuppressive effects when stimulated in vitro. In a murine model of hematopoietic stem cell transplantation, CAR-modified Tregs were more effective in preventing the development of graft-versus-host disease compared with polyclonal Tregs. The results of this study lay the groundwork for the further evaluation of CAR-expressing Tregs in the prevention or treatment of transplant complications.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; VERSUS-HOST-DISEASE; FOXP3 EXPRESSION; SUBPOPULATION; AUTOIMMUNE; RECEPTOR; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 May 2019 10:27 |
| Last Modified: | 17 May 2019 10:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3167 |
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