Soria, Francesco and Shariat, Shahrokh F. and Lerner, Seth P. and Fritsche, Hans-Martin and Rink, Michael and Kassouf, Wassim and Spiess, Philippe E. and Lotan, Yair and Ye, Dingwei and Fernandez, Mario I. and Kikuchi, Eiji and Chade, Daher C. and Babjuk, Marko and Grollman, Arthur P. and Thalmann, George N. (2017) Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC). WORLD JOURNAL OF UROLOGY, 35 (3). pp. 379-387. ISSN 0724-4983, 1433-8726
Full text not available from this repository. (Request a copy)Abstract
Upper-tract urothelial carcinoma (UTUC) is a relatively uncommon disease with limited available evidence on specific topics. The purpose of this article was to review the previous literature to summarize the current knowledge about UTUC epidemiology, diagnosis, preoperative evaluation and prognostic assessment. Using MEDLINE, a non-systematic review was performed including articles between January 2000 and February 2016. English language original articles, reviews and editorials were selected based on their clinical relevance. UTUC accounts for 5-10 % of all urothelial cancers, with an increasing incidence. UTUC and bladder cancer share some common risk factors, even if they are two different entities regarding practical, biological and clinical characteristics. Aristolochic acid plays an important role in UTUC pathogenesis in certain regions. It is further estimated that approximately 10 % of UTUC are part of the hereditary non-polyposis colorectal cancer spectrum disease. UTUC diagnosis remains mainly based on imaging and endoscopy, but development of new technologies is rapidly changing the diagnosis algorithm. To help the decision-making process regarding surgical treatment, extent of lymphadenectomy and selection of neoadjuvant systemic therapies, predictive tools based on preoperative patient and tumor characteristics have been developed. Awareness regarding epidemiology, diagnosis, preoperative evaluation and prognostic assessment changes is essential to correctly diagnose and manage UTUC patients, thereby potentially improving their outcomes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | UPPER URINARY-TRACT; TRANSITIONAL-CELL CARCINOMA; RADICAL NEPHROURETERECTOMY; URETEROSCOPIC BIOPSY; ONCOLOGIC OUTCOMES; LYNCH SYNDROME; RENAL PELVIS; TUMOR; IMPACT; SMOKING; UTUC; Epidemiology; Risk factor; Diagnosis; New technologies; Predictive tools; Prognosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 14 Feb 2019 15:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/317 |
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