Sauter, A. and Machura, K. and Neubauer, B. and Kurtz, Armin and Wagner, Charlotte (2008) Development of renin expression in the mouse kidney. KIDNEY INTERNATIONAL, 73 (1). pp. 43-51. ISSN 0085-2538, 1523-1755
Full text not available from this repository. (Request a copy)Abstract
During metanephric kidney development, renin is expressed in the walls of larger intrarenal arteries, but is restricted to the terminal part of the preglomerular arterioles in the adult kidney. Our study describes the three-dimensional development of renin expression in mouse kidneys during fetal and postnatal life. Renin immunoreactivity first appeared at day 14 of development in the cells expressing alpha-smooth muscle actin (alpha SMA) in the arcuate arteries. Before adulthood, the branching of the arcuate arterial tree increased exponentially and renin expression shifted from proximal to distal parts of the tree. Renin expression at branching points or in the cones of growing vessels was not seen. Instead, renin expression appeared after vessel walls and branches were already established, disappeared a few days later, and remained only in the juxtaglomerular regions of afferent arterioles. In these arterioles, coexpression of renin and aSMA disappeared gradually, with the terminal cells expressing only renin. At all stages of kidney development, renin expression among comparable vessel segments was heterogeneous. Renin expression remained stable after it reached the terminal parts of afferent arterioles.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENDOTHELIAL GROWTH-FACTOR; BLOOD-VESSEL FORMATION; DEVELOPING RAT-KIDNEY; CONTAINING CELLS; ANGIOTENSIN-SYSTEM; JUXTAGLOMERULAR APPARATUS; ELECTRON-MICROSCOPY; FETAL DEVELOPMENT; GENE-EXPRESSION; PDGF-B; renal vessel; alpha-smooth muscle actin; juxtaglomerular cell; branching; three-dimensional reconstruction |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Nov 2020 10:40 |
| Last Modified: | 18 Nov 2020 10:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31702 |
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