Goetz, Angela K. and Boeger, Carsten A. and Popal, Massoud and Banas, Bernhard and Kraemer, Bernhard K. (2008) Effect of membrane flux and dialyzer biocompatibility on survival in end-stage diabetic nephropathy. NEPHRON CLINICAL PRACTICE, 109 (3). C154-C160. ISSN 1660-2110,
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Aims: We examined the effects of dialyzer membrane flux and biocompatibility on mortality in diabetic dialysis patients. Methods: We enrolled 402 prevalent chronic hemodialysis patients from 30 centers in Germany in 1999 for a prospective observational study until 2003. We compared 2 groups in post hoc analysis: high-flux (HF, n = 166) versus low-flux (LF, n = 236) membrane, and high biocompatibility (HB, n = 300) versus low biocompatibility (LB, n = 102). All-cause mortality (ACM) was the primary endpoint. Death causes were the secondary endpoints. Results: Multivariate Cox regression analysis showed no significant difference in risk for ACM with respect to flux ( hazard ratio, HR, 0.79; p = 0.08; ACM 63% in HF vs. 70% in LF dialysis) and biocompatibility level (HR 1.00; p = 0.98; ACM 67% for HB vs. 66% for LB). The multivariate analysis of different causes of death did not reveal any outcome differences dependent on flux and biocompatibility level apart from a slightly better cumulative survival regarding the death cause 'infectious' in our HF dialysis group (HR 0.48; p = 0.07, Kaplan-Meier analysis p = 0.03). Conclusion: Our data indicate that mortality of hemodialysis patients with type-2 diabetic nephropathy is influenced neither by dialyzer flux level nor by biocompatibility. Copyright (c) 2008 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEMODIALYSIS-PATIENTS; MAINTENANCE HEMODIALYSIS; DIALYSIS PATIENTS; LONG-TERM; INHIBITORS; MORTALITY; THERAPY; HEMO; diabetic nephropathy; survival; end-stage diabetic nephropathy; dialysis membrane; membrane flux; dialyzer biocompatibility |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Nov 2020 06:52 |
| Last Modified: | 23 Nov 2020 06:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31729 |
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