Doehnel, Katrin and Sommer, Monika and Lbach, Bernd and Rothmayr, Christoph and Meinhardt, Joerg and Hajak, Goeran (2008) Neural correlates of emotional working memory in patients with mild cognitive impairment. NEUROPSYCHOLOGIA, 46 (1). pp. 37-48. ISSN 0028-3932,
Full text not available from this repository. (Request a copy)Abstract
Emotional stimuli can have beneficial effects on memory in healthy aged subjects and partly on patients with dementia. So far, no experimental study has explored the effects of memory for emotional stimuli in patients with mild cognitive impairment (MCI), a concept that describes a transitional state between normal aging and dementia. The present fMRI study explored working memory for emotional stimuli in 16 patients with amnestic MCI (aMCI) and 16 healthy aged participants. Subjects performed an n-back task (2-back) with neutral, positive, and negative emotional pictures. The analysis focused on target processing. Results showed that groups did not differ in working memory performance. In healthy aged participants emotional targets had no significant impact on working memory. In patients with aMCI a negativity bias was observed, indicating that negative targets were better remembered compared to neutral and positive targets. Regarding fMRI results, both groups showed an increase in functional activity in prefrontal and lateral parietal brain regions associated with target processing. As a key result, we observed significant group by emotion interaction effects in the precuneus. Healthy aged participants showed a signal decrease in the left precuneus for positive compared to neutral targets. The precuneus deactivation in healthy aged participants may indicate a disengagement of self-referential processes towards task-related processes. Patients with aMCI revealed a signal increase in the right precuneus for negative compared to neutral targets. This increase in precuneus activity, combined with a behavioural facilitation effect, may indicate a mechanism to compensate disease related processes in aMCI. (C) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORTICAL MIDLINE STRUCTURES; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; DECLARATIVE MEMORY; NEGATIVITY BIAS; DEFAULT MODE; BRAIN; FMRI; INFORMATION; ACTIVATION; MCI; fMRI; emotion; memory; precuneus |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Nov 2020 07:38 |
| Last Modified: | 23 Nov 2020 07:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31736 |
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