Koelwel, Christoph and Rothschenk, Stefan and Fuchs-Koelwel, Barbara and Gabler, Bernhard and Lohmann, Chris and Goepferich, Achim (2008) Alginate inserts loaded with epidermal growth factor for the treatment of keratoconjunctivitis sicca. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 13 (3). pp. 221-231. ISSN 1083-7450,
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We developed and tested ocular inserts containing epidermal growth factor (EGF) for a causal treatment of keratoconjunctivitis sicca (KCS). The inserts, consisting of different alginates with hydroxyethylcellulose (HEC) as a lubricant and release modifier, released EGF over time periods ranging from a few hours up to several days. The stability of EGF was high, having a protein half-life of approximately 548 days. A clinical pilot study suggests an amelioration of both the main symptoms and the objective criteria: tear film break-up (BUT) time and lissamine green score. Our results show that EGF treatment of KCS is highly promising.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DRY EYE; CONJUNCTIVA; TEARS; dry eye; ocular insert; alginates; EGF |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Nov 2020 07:53 |
| Last Modified: | 23 Nov 2020 07:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31750 |
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