Prantl, Lukas and Fichtner-Feigl, Stefan and Hofstaedter, Ferdinand and Lenich, Andreas and Eisenmann-Klein, Marita and Schreml, Stephan (2008) Flow cytometric analysis of peripheral blood lymphocyte subsets in patients with silicone breast implants. PLASTIC AND RECONSTRUCTIVE SURGERY, 121 (1). pp. 25-30. ISSN 0032-1052, 1529-4242
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Background: As there is still controversy regarding the effects of silicone breast implants on the immune system, the current study investigated the composition of peripheral blood lymphocytes of patients after augmentation mammaplasty with silicone breast implants. Methods: The authors' prospective study included 41 female patients (average age, 40 12 years) with unilateral/bilateral capsular contracture (Baker types I through TV) after cosmetic breast augmentation. Other fibrosing or autoimmunologic diseases were excluded at the time of implantation. Peripheral blood samples from all patients were examined (n = 41). Cells positive to antigens CD3, CD4, CD8, CD19, and CD16/CD56 were assessed by flow cytometric analysis and compared with a reference range of hematologically normal adults. Results: The vast majority of the peripheral blood lymphocytes were T lymphocytes (CD3(+); mean, 74.4 percent; range, 21.1 to 76.6 percent). The mean percentage of B lymphocytes (CD3(-)/CD19(+)) was 11.3 percent (range, 9.9 to 12.6 percent). A small percentage (mean, 11 percent; range, 9.1 to 12.9 percent) consisted of natural killer cells (CD3(-)/CD16(+)/CD56(+)). The peripheral blood T-lymphocyte subsets were CD3(+)/CD4(+) with a mean of 45.7 percent (range, 42.9 to 48.5 percent) and CD3(+)/CD8(+) with a mean of 22.1 percent (range, 19.8 to 24.3 percent), similar to those in healthy controls. Conclusions: No statistically significant difference in the distribution of peripheral blood lymphocytes could be detected in patients with silicone breast implants in comparison with other Caucasian adults. As far as lymphocytes are concerned, there was no evidence of systemic proinflammatory effects of silicone breast implants.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONNECTIVE-TISSUE DISEASES; OF-THE-LITERATURE; CAPSULAR CONTRACTURE; SMOOTH SILICONE; LONG-TERM; GEL; RISK; AUGMENTATION; EXPLANTATION; STIMULATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Nov 2020 10:25 |
| Last Modified: | 23 Nov 2020 10:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31763 |
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