Budweiser, Stephan and Heidtkamp, Felix and Joerres, Rudolf A. and Heinemann, Frank and Arzt, Michael and Schroll, Stephan and Schmidbauer, Kathrin and Hitzl, Andre P. and Pfeifer, Michael (2008) Predictive significance of the six-minute walk distance for long-term survival in chronic hypercapnic respiratory failure. RESPIRATION, 75 (4). pp. 418-426. ISSN 0025-7931, 1423-0356
Full text not available from this repository. (Request a copy)Abstract
Background: The 6-min walk distance ( 6-MWD) is a global marker of functional capacity and prognosis in chronic obstructive pulmonary disease ( COPD), but less explored in other chronic respiratory diseases. Objective: To study the role of 6-MWD in chronic hypercapnic respiratory failure ( CHRF). Methods: In 424 stable patients with CHRF and non-invasive ventilation ( NIV) comprising COPD ( n = 197), restrictive diseases ( RD; n = 112) and obesity-hypoventilation- syndrome ( OHS; n = 115), the prognostic value of 6-MWD for long- term survival was assessed in relation to that of body mass index (BMI), lung function, respiratory muscle function and laboratory parameters. Results: 6-MWD was reduced in patients with COPD ( median 280 m; quartiles 204/350 m) and RD ( 290 m; 204/362 m) compared to OHS ( 360 m; 275/440 m; p <0.001 each). Overall mortality during 24.9 (13.1/40.5) months was 22.9%. In the 424 patients with CHRF, 6-MWD independently predicted mortality in addition to BMI, leukocytes and forced expiratory volume in 1 s ( p <0.05 each). In COPD, 6-MWD was strongly associated with mortality using the median [ p <0.001, hazard ratio ( HR) = 3.75, 95% confidence interval (CI): 2.24-6.38] or quartiles as cutoff levels. In contrast, 6-MWD was only significantly associated with impaired survival in RD patients when it was reduced to 204 m or less (1st quartile; p = 0.003, HR = 3.31, 95% CI: 1.73-14.10), while in OHS 6-MWD had not any prognostic value. Conclusions: In patients with CHRF and NIV, 6-MWD was predictive for long- term survival particularly in COPD. In RD only severely reduced 6-MWD predicted mortality, while in OHS 6-MWD was relatively high and had no prognostic value. These results support a disease-specific use of 6-MWD in the routine assessment of patients with CHRF. Copyright (C) 2007 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OBSTRUCTIVE PULMONARY-DISEASE; BODY-MASS INDEX; HOME MECHANICAL VENTILATION; OBESITY-HYPOVENTILATION SYNDROME; POSITIVE-PRESSURE VENTILATION; NONINVASIVE VENTILATION; OXYGEN-THERAPY; OXIDATIVE STRESS; COPD PATIENTS; LUNG-DISEASE; cardiopulmonary exercise test; chronic obstructive pulmonary disease; chronic respiratory failure; non-invasive mechanical ventilation; prognostic factor; respiratory diseases |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Nov 2020 10:48 |
| Last Modified: | 23 Nov 2020 10:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31770 |
Actions (login required)
 |
View Item |
