Kirchner, Gabriele I. and Tischendorf, Jens J. W. and Bleck, Joerg and Wagner, Siegfried and Caselitz, Martin and Klempnauer, Juergen and Manns, Michael P. and Gebel, Michael (2008) Perihilar lymph nodes in patients with primary sclerosing cholangitis with and without cholangiocellular carcinoma. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 43 (11). pp. 1366-1370. ISSN 0036-5521, 1502-7708
Full text not available from this repository. (Request a copy)Abstract
Objective. Enlarged perihilar lymph nodes have been described in patients with primary sclerosing cholangitis (PSC). The aim of the study was to determine the clinical relevance of perihilar lymph nodes in PSC patients with and without cholangiocellular carcinoma (CCC). Material and methods. The status of perihilar lymph nodes was investigated in 117 patients with PSC using "high-end'' ultrasound. Thirty-five of the 117 PSC patients had histologically proven CCC. Lymph node status was correlated with the presence of CCC and inflammatory bowel disease (IBD). Results. Seventy-three percent of PSC patients without CCC and 86% of patients with CCC had enlarged perihilar lymph nodes (NS). In CCC patients, the width of lymph nodes was significantly larger (12+/-6 mm versus 8+/-4 mm; p = 0.0001), and the length: width ratio (2.15+/-0.7:1 versus 2.5+/-0.6:1; p = 0.004) of the lymph nodes was significantly lower. Thirty-seven percent of PSC patients without CCC and 57% of patients with PSC and CCC had multiple perihilar lymph nodes (p = 0.04). In all patients, the presence versus absence of IBD had no influence on the number (84% versus 74%,) and size of perihilar lymph nodes (length: 21910 mm versus 1997 mm). Lymph node status did not correlate with the number of episodes of cholangitis. Conclusions. Enlarged perihilar lymph nodes are characteristic of patients with PSC. Since perihilar lymph nodes are not predictive of the presence of complicating CCC, such patients should not be excluded from liver transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; CHRONIC HEPATITIS-C; BILE-DUCT STENOSES; LIVER-TRANSPLANTATION; PERIHEPATIC LYMPHADENOPATHY; CLINICAL-COURSE; CHOLANGIOCARCINOMA; SURVIVAL; MARKER; Cholangiocellular carcinoma; inflammatory bowel disease; perihilar lymph nodes; primary sclerosing cholangitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Nov 2020 11:13 |
| Last Modified: | 23 Nov 2020 11:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31776 |
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