Beckmann, Johannes and Kees, Frieder and Schaumburger, Jens and Kalteis, Thomas and Lehn, Norbert and Grifka, Joachim and Lerch, Klaus (2007) Tissue concentrations of vancomycin and moxifloxacin in periprosthetic infection in rats. ACTA ORTHOPAEDICA, 78 (6). pp. 766-773. ISSN 1745-3674, 1745-3682
Full text not available from this repository. (Request a copy)Abstract
Background A one-step exchange of an endoprosthesis with periprosthetic infection requires effective antibiotics at high concentrations around the endoprosthesis. We evaluated the tissue distribution of vancomycin and moxifloxacin in a standardized in vivo model of periprosthetic infection. Methods 36 male rats with periprosthetic infection of the left hind leg, induced by a standardized procedure, received either antibiotic treatment with vancomycin or moxifloxacin twice daily for 2 weeks, or a sham treatment. After the last administration, different tissues from each animal were evaluated for concentrations of antibiotic. Results Compared to plasma, the tissue concentrations of moxifloxacin were higher in all tissues investigated (lung, muscle, fat, bone) and the tissue-plasma ratio of moxifloxacin was considerably higher than that of vancomycin. The concentrations of moxifloxacin were equally high in the infected and the uninfected hind leg, whereas the vancomycin concentrations were significantly higher in the infected leg. Interpretation The standardized model of periprosthetic infection described here can be extrapolated to different bacterial and mycotic pathogens, and also to different antibiotics or therapeutic regimes. It provides a way of correlating tissue concentrations with clinical outcome in future studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TOTAL KNEE ARTHROPLASTY; RESISTANT STAPHYLOCOCCUS-AUREUS; INTRAOPERATIVE GRAM STAIN; TOTAL HIP ARTHROPLASTIES; IN-VITRO; CLINICAL PHARMACOKINETICS; OSTEOMYELITIS; SERUM; BONE; LEVOFLOXACIN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Orthopädie Medicine > Lehreinheit Pharmakologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Nov 2020 08:00 |
| Last Modified: | 25 Nov 2020 08:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31814 |
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