Ludwig, Christine and Wagner, Ralf (2007) Virus-like particles - universal molecular toolboxes. CURRENT OPINION IN BIOTECHNOLOGY, 18 (6). pp. 537-545. ISSN 0958-1669
Full text not available from this repository. (Request a copy)Abstract
Virus-like particles (VLPs) are highly organised spheres that self-assemble from virus-derived structural antigens. These stable and versatile subviral particles possess excellent adjuvant properties capable of inducing innate and cognate immune responses. Commercialised VLP-based vaccines have been successful in protecting humans from hepatitis B virus (HBV) and human papillomavirus (HPV) infection and are currently explored for their potential to combat other infectious diseases and cancer. Much insight into VLP-mediated immune stimulation and optimised VLP design has been gained from human immunodeficiency virus (HIV)-derived VLPs presenting promising components of current AIDS vaccine approaches. Owing to their unique features, VLPs and virosomes, the in vitro-reconstituted VLP counterparts, have recently gained ground in the field of nanobiotechnology as organic templates for the development of new biomaterials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN-PAPILLOMAVIRUS TYPE-16; RANDOMIZED CONTROLLED-TRIAL; VESICULAR STOMATITIS-VIRUS; ACTIVATE DENDRITIC CELLS; INFLUENZA VIROSOMES; IMMUNE-RESPONSES; NEUTRALIZING ANTIBODIES; HIV-1 ENVELOPE; INSECT CELLS; HEPATITIS-B; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 10 Dec 2020 09:05 |
| Last Modified: | 10 Dec 2020 09:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31829 |
Actions (login required)
 |
View Item |
