Kraemer, B. K. and Banas, M. and Banas, B. (2007) Medication-induced impairment of renal function - What is important? INTERNIST, 48 (12). 1376-+. ISSN 0020-9554,
Full text not available from this repository. (Request a copy)Abstract
Non-steroidal antiphlogistics and COX-2 inhibitors routinely cause sodium retention and a blood pressure increase by about 5 mmHg, a decrease in renal function (by about 10 ml/min) and in 1-2% an acute renal failure. Prevention is possible by short-term, low-dose application, avoidance of dehydration, controlling serum creatinine levels 1 week after start of treatment in high-risk groups. Aminoglycosides cause acute renal failure in 10-20% which can be prevented by once daily dosing, meticulous drug monitoring. Radio contrast media cause, mostly dependent on baseline renal function, in 0-50% a radiocontrast-induced nephropathy. This can be prohibited with hydration, low volume of contrast medium, and low- (or iso)osmolar contrast medium. New preparations of vancomycin go along with a greatly reduced rate of nephrotoxicity. Drug monitoring and avoidance of a combination therapy with aminoglycosides will help to reduce toxicity. Medication-induced acute interstitial nephritis is a relevant differential diagnosis in acute renal failure: stop implicated medication, consider steroid application!.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONTRAST-INDUCED NEPHROPATHY; PREVENTION; ACETYLCYSTEINE; FAILURE; THEOPHYLLINE; acute renal failure; aminoglycoside; radiocontrast agent; non-steroidal antiphlogistic drugs; vancomycin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Nov 2020 09:04 |
| Last Modified: | 25 Nov 2020 09:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31854 |
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