Gerle, Borbala and Koroknai, Anita and Fejer, Gyoergy and Bakos, Agnes and Banati, Ferenc and Szenthe, Kalman and Wolf, Hans and Niller, Hans Helmut and Minarovits, Janos and Salamon, Daniel (2007) Acetylated histone H3 and H4 mark the upregulated LMP2A promoter of Epstein-Barr virus in lymphoid cells. JOURNAL OF VIROLOGY, 81 (23). pp. 13242-13247. ISSN 0022-538X, 1098-5514
Full text not available from this repository. (Request a copy)Abstract
We analyzed the levels of acetylated histones and histone H3 dimethylated on lysine 4 (H3K4me2) at the LMP2A promoter (LMP2Ap) of Epstein-Barr virus in well-characterized type I and type III lymphoid cell line pairs and additionally in the nasopharyngeal carcinoma cell line C666-1 by using chromatin immunoprecipitation. We found that enhanced levels of acetylated histones marked the upregulated LMP2Ap in lymphoid cells. In contrast, in C666-1 cells, the highly DNA-methylated, inactive LMP2Ap was also enriched in acetylated histones and H3K4me2. Our results suggest that the combinatorial effects of DNA methylation, histone acetylation, and H3K4me2 modulate the activity of LMP2Ap.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESOLUTION METHYLATION ANALYSIS; PROTEIN-DNA BINDING; RBP-J-KAPPA; NUCLEAR ANTIGEN-2; IN-VIVO; TRANSCRIPTIONAL REPRESSION; DEACETYLASE COMPLEX; GENE-EXPRESSION; CPG METHYLATION; HUMAN GENOME; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Nov 2020 09:34 |
| Last Modified: | 25 Nov 2020 09:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31865 |
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