Mildner, Alexander and Schmidt, Hauke and Nitsche, Mirko and Merkler, Doron and Hanisch, Uwe-Karsten and Mack, Matthias and Heikenwalder, Mathias and Brueck, Wolfgang and Priller, Josef and Prinz, Marco (2007) Microglia in the adult brain arise from Ly-6C(hi)CCR2(+) monocytes only under defined host conditions. NATURE NEUROSCIENCE, 10 (12). pp. 1544-1553. ISSN 1097-6256, 1546-1726
Full text not available from this repository. (Request a copy)Abstract
Microglia are crucially important myeloid cells in the CNS and constitute the first immunological barrier against pathogens and environmental insults. The factors controlling microglia recruitment from the blood remain elusive and the direct circulating microglia precursor has not yet been identified in vivo. Using a panel of bone marrow chimeric and adoptive transfer experiments, we found that circulating Ly-6C(hi)CCR2(+) monocytes were preferentially recruited to the lesioned brain and differentiated into microglia. Notably, microglia engraftment in CNS pathologies, which are not associated with overt blood-brain barrier disruption, required previous conditioning of brain (for example, by direct tissue irradiation). Our results identify Ly-6C(hi)CCR2(+) monocytes as direct precursors of microglia in the adult brain and establish the importance of local factors in the adult CNS for microglia engraftment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CENTRAL-NERVOUS-SYSTEM; GREEN FLUORESCENT PROTEIN; MARROW-DERIVED MICROGLIA; BETA-AMYLOID DEPOSITION; NF-KAPPA-B; BONE-MARROW; HEMATOPOIETIC-CELLS; STEM-CELLS; IN-VIVO; AUTOIMMUNE ENCEPHALOMYELITIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Nov 2020 10:25 |
| Last Modified: | 25 Nov 2020 10:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31871 |
Actions (login required)
 |
View Item |
