Fichtner-Feigl, Stefan and Debus, E. -S. and Schlitt, H. -J. (2007) Fibrogenesis in Crohn's disease. VISZERALCHIRURGIE, 42 (6). pp. 346-350. ISSN 1435-3067,
Full text not available from this repository. (Request a copy)Abstract
Over one-third of patients with Crohn's disease eventually will develop intestinal stenosis with the need for surgical intervention. While the pathophysiology of the inflammatory response in Crohn's disease has been investigated extensively, the knowledge of intestinal fibrogenesis is limited. Fibrotic organ remodelling results from a complex interplay of genetic factors, acute and chronic inflammation, activation of mesenchymal cells and the timely expression of several proinflammatory and profibrotic cytokines. The combination of those factors leads to enhanced deposition of extracellular matrix with consecutive fibrosis of the intestine. Through investigation of the pathophysiologic processes of the fibrogenesis in Crohn's disease the basis for specific antifibrotic therapies can be built.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; TISSUE GROWTH-FACTOR; NF-KAPPA-B; PLASMINOGEN-ACTIVATOR INHIBITOR; MATRIX METALLOPROTEINASES; INTESTINAL MYOFIBROBLASTS; FACTOR-BETA; IGF-I; EXPRESSION; FIBROSIS; fibrosis; stenosis; Crohn's disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Nov 2020 13:37 |
| Last Modified: | 25 Nov 2020 13:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31892 |
Actions (login required)
 |
View Item |
