Ali, Shafaqat and Hubert, Michael and Kollewe, Christian and Bischoff, Stephan C. and Falk, Werner and Martin, Michael U. (2007) IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104 (47). pp. 18660-18665. ISSN 0027-8424,
Full text not available from this repository. (Request a copy)Abstract
Lack of the IL-1 receptor accessory protein (IL-1RAcP) abrogates responses to IL-33 and IL-1 in the mouse thymoma clone EL-4 D6/76 cells. Reconstitution with full-length lL-1RAcP is sufficient to restore responsiveness to IL-33 and IL-1. IL-33 activates IL-1 receptor-associated kinase-1, cJun-N-terminal kinase, and the NF-kappa B pathway in an IL-1RAcP-dependent manner and results in IL-2 release. IL-33 is able to induce the release of proinflammatory cytokines in bone marrow-derived (BMD) mast cells, indicating that IL-33 may have a proinflammatory potential like its relatives IL-1 and IL-18, in addition to its Th2-skewing properties in the adaptive response described previously. Blocking of murine IL-1RAcP with the neutralizing antibody 4C5 inhibits response of mouse thymoma cells and BMD mast cells to IL-33. The interaction of either membrane-bound or soluble forms of lL-1RAcP and IL-33R alpha-chain depends on the presence of IL-33, as demonstrated by coimmuno-precipitation assays. These data demonstrate that IL-1RAcP is indispensable for IL-33 signaling. Furthermore, they suggest that IL-1RAcP is used by more than one alpha-chain of the IL-1 receptor family and thus may resemble a common beta-chain of that family.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NF-KAPPA-B; INTERLEUKIN-1 RECEPTOR; MOLECULAR-CLONING; CRYSTAL-STRUCTURE; THYMOMA CELLS; ST2 RECEPTOR; SOLUBLE FORM; FAMILY; CYTOKINE; KINASE; IL-1RAcP; IL-33 signaling; IL-33 receptor complex; IL-1 receptor family |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Nov 2020 11:53 |
| Last Modified: | 26 Nov 2020 11:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31904 |
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