Thon, V. and Haerle, P. and Schoelmerich, J. and Kuklinek, P. and Lokaj, J. and Straub, Rainer H. (2007) Lack of dehydroepiandrosterone in type I and II hereditary angioedema and role of danazol in steroid hormone conversion. ALLERGY, 62 (11). pp. 1320-1325. ISSN 0105-4538,
Full text not available from this repository.Abstract
Background: Hereditary angioedema (HAE) is successfully treated with danazol, a therapeutic steroid compound. To investigate hormones of the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axis in patients with HAE with and without danazol. Methods: We included 16 patients with type I HAE, nine patients with type II HAE, and 16 healthy subjects. Serum levels of adrenocorticotropic hormone (ACTH), cortisol, androstenedione, dehydroepiandrosterone (DHEA), free testosterone, and 17 beta-oestradiol were measured. Results: Serum levels of ACTH were markedly decreased in patients with type II HAE compared to the other groups (P < 0.001). Serum cortisol was similar between groups but danazol treatment decreased cortisol levels, particularly in women (P = 0.019). Serum levels of DHEA were significantly decreased in all patients with type I and II HAE compared to controls (P < 0.05), which was only partly dependent on prior danazol therapy as patients without danazol had also decreased serum levels of DHEA (P < 0.05). Furthermore, free testosterone serum levels were markedly increased in patients under danazol (P < 0.005) and the ratio of 17 beta-oestradiol/free testosterone was significantly decreased in these patients (P < 0.005). Conclusions: This study demonstrated decreased DHEA in patients with type I and II HAE independent of danazol therapy, which was particularly evident in women. It also demonstrates that danazol induced a marked up-regulation of free testosterone in relation to precursors and downstream 17 beta-oestradiol. In HAE, there seems to be a primary lack of the adrenal androgen DHEA.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | C1 INHIBITOR; C1-INHIBITOR DEFICIENCY; MONONUCLEAR-CELLS; BETA-ENDORPHIN; EXPRESSION; WOMEN; GLOBULIN; SULFATE; adrenocorticotropic hormone; cortisol; danazol; dehydroepiandrosterone; hereditary angioedema; testosterone |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Nov 2020 08:26 |
| Last Modified: | 30 Nov 2020 08:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31939 |
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