Herwig, Uwe and Fallgatter, A. J. and Hoeppner, J. and Eschweiler, G. W. and Kron, M. and Hajak, G. and Padberg, F. and Naderi-Heiden, A. and Abler, B. and Eichhammer, P. and Grossheinrich, N. and Hay, B. and Kammer, T. and Langguth, B. and Laske, C. and Plewnia, C. and Richter, M. M. and Schulz, M. and Unterecker, S. and Zinke, A. and Spitzer, M. and Schonfeldt-Lecuona, C. (2007) Antidepressant effects of augmentative transcranial magnetic stimulation - Randomised multicentre trial. BRITISH JOURNAL OF PSYCHIATRY, 191. pp. 441-448. ISSN 0007-1250,
Full text not available from this repository. (Request a copy)Abstract
Background Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a new treatment option for depression. Previous studies were performed with low sample sizes in single centres and reported heterogeneous results. Aims To investigate the efficacy of as augmentative treatment in depression. Method In a randomised, double-blind, sham-controlled multicentre trial 127 patients with moderate to severe depressive episodes were randomly assigned to real or sham stimulation for 3 weeks in addition to simultaneously initiated antidepressant medication. Results We found no difference in the responder rates of the real and the sham treatment groups (31% in each) or in the decrease of the scores on the depression rating scales. Conclusions The data do not support previous reports from smaller samples indicating an augmenting or accelerating antidepressant effect of rTMS. Further exploration of the possible efficacy of other stimulation protocols or within selected sub-populations of patients is necessary.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MAJOR DEPRESSIVE DISORDER; DOUBLE-BLIND; RESISTANT DEPRESSION; PREFRONTAL CORTEX; TMS TREATMENT; EFFICACY; RTMS; METAANALYSIS; VENLAFAXINE; SERTRALINE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Nov 2020 09:47 |
| Last Modified: | 30 Nov 2020 09:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31949 |
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