Holler, Ernst (2007) Progress in acute graft versus host disease. CURRENT OPINION IN HEMATOLOGY, 14 (6). pp. 625-631. ISSN 1065-6251,
Full text not available from this repository. (Request a copy)Abstract
Purpose of review The aim of this article is to highlight both experimental and clinical studies contributing to our present understanding of acute graft versus host disease. Recent findings New cellular players and new molecules in induction, modulation and treatment of graft versus host disease are reported. The contribution of antigen presenting cells to induction of graft versus host disease and graft versus leukemia effects is well understood in animal models and now needs confirmation in human analyses. Both, regulatory T cells and mesenchymal stem cells are a new hope for prophylaxis and treatment. Receptors of innate immunity, homing molecules and chemokines regulate activation and trafficking of these cellular players and may be used for selective blockade, activation or cell selection. Summary Better understanding of the early events involved in graft versus host disease should allow risk adapted and more precise early or even preemptive treatment of graft versus host disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; REGULATORY T-CELLS; BONE-MARROW-TRANSPLANTATION; DENDRITIC CELLS; METHYLENETETRAHYDROFOLATE REDUCTASE; NOD2/CARD15 VARIANTS; LANGERHANS CELLS; CLINICAL-TRIALS; IFN-GAMMA; B-CELLS; acute GvHD; antigen presenting cells; cytokines; regulatory T cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Nov 2020 07:44 |
| Last Modified: | 27 Nov 2020 07:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31955 |
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