Schlett, Christopher L. and Hendel, Thomas and Hirsch, Jochen and Weckbach, Sabine and Caspers, Svenja and Schulz-Menger, Jeanette and Ittermann, Till and von Knobelsdorff-Brenkenhoff, Florian and Ladd, Susanne C. and Moebus, Susanne and Stroszczynski, Christian and Fischer, Beate and Leitzmann, Michael and Kuhl, Christiane and Pessler, Frank and Hartung, Dagmar and Kemmling, Yvonne and Hetterich, Holger and Amunts, Katrin and Guenther, Matthias and Wacker, Frank and Rummeny, Ernst and Kauczor, Hans-Ulrich and Forsting, Michael and Voelzke, Henry and Hosten, Norbert and Reiser, Maximilian F. and Bamberg, Fabian (2016) Quantitative, Organ-Specific Interscanner and Intrascanner Variability for 3 T Whole-Body Magnetic Resonance Imaging in a Multicenter, Multivendor Study. INVESTIGATIVE RADIOLOGY, 51 (4). pp. 255-265. ISSN 0020-9996, 1536-0210
Full text not available from this repository. (Request a copy)Abstract
Introduction Whole-body magnetic resonance (MR) imaging is increasingly implemented in population-based cohorts and clinical settings. However, to quantify the variability introduced by the different scanners is essential to make conclusions about clinical and biological data, and relevant for internal/external validity. Thus, we determined the interscanner and intrascanner variability of different 3 T MR scanners for whole-body imaging. Methods Thirty volunteers were enrolled to undergo multicentric, interscanner as well intrascanner imaging as part of the German National Cohort pilot studies. A comprehensive whole-body MR protocol was installed at 9 sites including 7 different MR scanner models by all 4 major vendors. A set of quantitative, organ-specific measures (n = 20; eg, volume of brain's gray/white matter, pulmonary trunk diameter, vertebral body height) were obtained in blinded fashion. Reproducibility was determined using mean weighted relative differences and intraclass correlation coefficients. Results All participants (44 +/- 14 years, 50% female) successfully completed the imaging protocol except for two because of technical issues. Mean scan time was 2 hours and 32 minutes and differed significantly across scanners (range, 1 hour 59 minutes to 3 hours 12 minutes). A higher reproducibility of obtained measurements was observed for intrascanner than for interscanner comparisons (intraclass correlation coefficients, 0.80 +/- 0.17 vs 0.60 +/- 0.31, P = 0.005, respectively). In the interscanner comparison, mean relative difference ranged from 1.0% to 53.2%. Conversely, in the intrascanner comparison, mean relative difference ranged from 0.1% to 15.6%. There were no statistical differences for intrascanner and interscanner reproducibility between the different organ foci (all P >= 0.24). Conclusions While whole-body MR imaging-derived, organ-specific parameters are generally associated with good to excellent reproducibility, smaller differences are obtained when using identical MR scanner models by a single vendor.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LEFT-VENTRICULAR MEASUREMENTS; OPERATOR INDUCED VARIABILITY; HEALTHY-VOLUNTEERS; MRI; REPRODUCIBILITY; DESIGN; UPDATE; BRAIN; SCAN; whole-body imaging; German National Cohort; reproducibility; population-based imaging; variability; 3 T magnetic resonance tomography |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Apr 2019 09:43 |
| Last Modified: | 03 Apr 2019 09:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3197 |
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