Agha, Ayman and Glockzin, Gabriel and Woenckhaus, Matthias and Dietmaier, Wolfgang and Iesalnieks, Igors and Schlitt, Hans J. (2007) Insular carcinomas of the thyroid exhibit poor prognosis and long-term survival in comparison to follicular and papillary T4 carcinomas. LANGENBECKS ARCHIVES OF SURGERY, 392 (6). pp. 671-677. ISSN 1435-2443,
Full text not available from this repository. (Request a copy)Abstract
Background Insular thyroid carcinoma was described as a tumor with aggressive behavior, and patients usually present themselves with an advanced tumor stage. Whether the insular component is an independent factor for poor prognosis remains unclear. Therefore, in the present study, we compared the survival of patients with advanced insular, follicular, and papillary thyroid cancer. Materials and methods The clinical behavior of tumors in three groups of patients with T4 thyroid carcinoma-8 patients with insular, 11 patients with follicular, and 21 patients with papillary thyroid carcinomas-was compared. Disease-free survival and disease-specific death were analyzed statistically. Cox regression analysis was used to evaluate the influence of histotype and other prognostic factors. Results At 3 years, survival was 37.5% (mean 26 months) among patients with insular thyroid carcinoma, 80% (mean 59 months) among those with follicular, and 89% (mean 126 months) among those with papillary thyroid carcinomas (p=0.007). Disease-free survival in patients without initial distant metastasis was worst in patients with insular thyroid carcinoma (20%) compared to those with follicular (75%) and those with papillary thyroid carcinomas (71%). Conclusion Patients with advanced insular thyroid carcinoma have a poorer outcome in comparison to patients with similar advanced stage who have follicular or papillary thyroid carcinoma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFREQUENT SUBTYPE; SOLID PATTERNS; COMPONENT; FEATURES; CANCER; GLAND; insular thyroid carcinoma; thyroid gland; survival; patient outcome; prognostic factor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Nov 2020 14:18 |
| Last Modified: | 30 Nov 2020 14:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31995 |
Actions (login required)
 |
View Item |
