Tamm, Ernst R. and Fuchshofer, Rudolf (2007) What increases outflow resistance in primary open-angle glaucoma? SURVEY OF OPHTHALMOLOGY, 52 (Suppl2). S101-S104. ISSN 0039-6257
Full text not available from this repository.Abstract
Intraocular pressure, the most critical risk factor for primary open-angle glaucoma is generated in the trabecular meshwork outflow pathways, which provide resistance to aqueous humor outflow. The resistance is increased in primary open-angle glaucoma, and changes in the quality and amount of the extracellular matrix in the juxtacanalicular region of the trabecular meshwork appear to be causatively involved. The extracellular matrix changes are very likely under control of transforming growth factor-beta 2 (TGF-beta 2), which is found at high concentrations in the aqueous humor of patients with primary open-angle glaucoma. Additional factors are thrombospondin-1, which activates TGF-beta 2 in vivo, and connective tissue growth factor, which is an important downstream mediator of the effects of TGF-beta 2 on trabecular meshwork extracellular matrix turnover. In contrast, bone morphogenetic protein-7 (BMP-7) strongly antagonizes fibrogenic actions of TGF-beta 2 on human trabecular meshwork cells, indicating that a pharmacological modulation of BMP-7 signalling might be a promising strategy to treat primary open-angle glaucoma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN TRABECULAR MESHWORK; BONE MORPHOGENETIC PROTEINS; AQUEOUS-HUMOR OUTFLOW; INNER WALL ENDOTHELIUM; GROWTH-FACTOR-BETA; HUMAN EYES; TGF-BETA-2; CELLS; EXPRESSION; FIBROSIS; extracellular matrix; intraocular pressure; primary open-angle glaucoma; trabecular meshwork; transforming growth factor-beta 2 |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm |
| Depositing User: | Petra Gürster |
| Date Deposited: | 08 Dec 2020 07:58 |
| Last Modified: | 08 Dec 2020 07:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32052 |
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