Muenzel, Daniela and Lehle, Karla and Haubner, Frank and Schmid, Christof and Birnbaum, Dietrich E. and Preuner, Juergen G. (2007) Impact of diabetic serum on endothelial cells: An in-vitro-analysis of endothelial dysfunction in diabetes mellitus type 2. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 362 (2). pp. 238-244. ISSN 0006-291X,
Full text not available from this repository. (Request a copy)Abstract
Diabetic endothelial dysfunction was characterized by altered levels of adhesion molecules and cytokines. Aim of our study was to evaluate the effects of diabetic serum on cell-growth and proinflammatory markers in human saphenous vein endothelial cells (HSVEC) from diabetic and non-diabetic patients. Diabetic serum showed (1) complementary proliferative activity for non-diabetic and diabetic HSVEC, (2) unchanged surface expression of adhesion molecules, and (3) elevated levels of sICAM-1 in HSVEC of all donors. The concentration of sVCAM-1 was increased only in diabetic cells. The proinflammatory state of diabetic HSVEC characterized by increased levels of cytokines was compensated. We concluded that even under normoglycemic conditions the serum itself contains critical factors leading to abnormal regulation of inflammation in diabetics. We introduced an in vitro model of diabetes representing the endothelial situation at the beginning of diabetes (non-diabetic cells/diabetic serum) as well as the diabetic chronic state (diabetic cells/diabetic serum). (C) 2007 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLYCATION END-PRODUCTS; CIRCULATING ADHESION MOLECULES; HUMAN UMBILICAL VEIN; GROWTH-FACTOR; E-SELECTIN; VASCULAR INFLAMMATION; INSULIN-RESISTANCE; SAPHENOUS-VEIN; KAPPA-B; DISEASE; endothelial cell; diabetes mellitus; diabetic serum; cell-growth; adhesion molecules; cytokines |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 07:39 |
| Last Modified: | 02 Dec 2020 07:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32066 |
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