Kulkarni, Vedant A. and Massie, Jennifer B. and Zauner, Florian and Murphy, Mark and Akeson, Wayne H. (2007) Novel biomechanical quantification methodology for lumbar intraforaminal spinal nerve adhesion in a laminectomy and disc injury rat model. JOURNAL OF NEUROSCIENCE METHODS, 166 (1). pp. 20-23. ISSN 0165-0270, 1872-678X
Full text not available from this repository. (Request a copy)Abstract
Spinal nerve fibrosis following injury or surgical intervention may play an important role in the pathophysiology of chronic back pain. In this current study, we demonstrate the role of biomechanical quantification of lumbar intraforaminal spinal nerve adhesion and tethering in the analysis of the post-laminectomy condition and describe a direct methodology to make this measurement. Twenty age-matched Sprague-Dawley male rats were divided into operative and non-operative (control) groups. Operative animals underwent a bilateral L5-L6 laminectomy with right-side L5-6 disc injury, a post-laminectomy pain model previously published by this lab. At eight weeks, animals were sacrificed and the strength of adhesion of the L5 intraforaminal spinal nerve to surrounding structures was quantified using a novel biomechanical methodology. Operative animals were found to have a significantly greater load to displace the intact right L5 spinal nerve through the intervertebral foramen when compared to control animals. The findings show that the post-laminectomy condition creates quantifiable fibrosis of the spinal nerve to surrounding structures and supports the conclusion that this fibrosis may play a role in the post-laminectomy pain syndrome. (C) 2007 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERIDURAL SCAR; DISKECTOMY; PAIN; SURGERY; MIMICS; ROOT; MRI; biomechanics; lumbar spine; laminectomy; fibrosis; failed back surgery syndrome; post-laminectomy pain syndrome |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 06:33 |
| Last Modified: | 02 Dec 2020 06:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32076 |
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