Schober, Franziska and Neumeler, Markus and Weigert, Johanna and Wurm, Sylvia and Wanninger, Josef and Schaffler, Andreas and Dada, Ashraf and Liebisch, Gerhard and Schmitz, Gerd and Aslanidis, Charalampos and Buechler, Christa (2007) Low molecular weight adiponectin negatively correlates with the waist circumference and monocytic IL-6 release. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 361 (4). pp. 968-973. ISSN 0006-291X,
Full text not available from this repository. (Request a copy)Abstract
Adiponectin circulates as trimer (LMW), hexamer (MMW) and high molecular weight multimer (HMW) but the distribution and effects of these isoforms have not been studied in detail. Monocytes were isolated from normal weight and overweight controls and patients with type 2 diabetes mellitus (T2D) and monocytic release of IL-6 positively correlated with the body mass index (BMI). HMW-adiponectin further enhanced and LMW-adiponectin reduced IL-6 release in monocytes. Systemic total adiponectin, and the HMW isoform were not different in these groups but MMW-adiponectin was lower in T2D, and LMW-adiponectin was reduced in the obese and T2D. Circulating LMW-adiponectin negatively correlated to monocytic IL-6 release. Systemic IL-6 was higher in the obese control group and T2D, respectively, but did not correlate with monocytic IL-6 secretion. Therefore, the current study indicates that HMW-adiponectin exerts pro- and LMW-adiponectin antiinflammatory effects and reduced LMW-adiponectin in obesity may partly contribute to elevated monocytic IL-6 release. (C) 2007 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TYPE-2 DIABETIC-PATIENTS; INTERLEUKIN-6 LEVELS; INSULIN-RESISTANCE; METABOLIC SYNDROME; MACROPHAGES; PROTEINS; DISEASE; PLASMA; ALPHA; CELLS; adiponectin isoforms; monocytes; body mass index; IL-6 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 09:45 |
| Last Modified: | 01 Dec 2020 09:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32082 |
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