Haimerl, Michael and Schlabeck, Mona and Verloh, Niklas and Zeman, Florian and Fellner, Claudia and Nickel, Dominik and Barreiros, Ana Paula and Loss, Martin and Stroszczynski, Christian and Wiggermann, Philipp (2016) Volume-assisted estimation of liver function based on Gd-EOB-DTPA-enhanced MR relaxometry. EUROPEAN RADIOLOGY, 26 (4). pp. 1125-1133. ISSN 0938-7994, 1432-1084
Full text not available from this repository. (Request a copy)Abstract
ObjectivesTo determine whether liver function as determined by indocyanine green (ICG) clearance can be estimated quantitatively from hepatic magnetic resonance (MR) relaxometry with gadoxetic acid (Gd-EOB-DTPA). MethodsOne hundred and seven patients underwent an ICG clearance test and Gd-EOB-DTPA-enhanced MRI, including MR relaxometry at 3 Tesla. A transverse 3D VIBE sequence with an inline T1 calculation was acquired prior to and 20 minutes post-Gd-EOB-DTPA administration. The reduction rate of T1 relaxation time (rrT1) between pre- and post-contrast images and the liver volume-assisted index of T1 reduction rate (LVrrT1) were evaluated. The plasma disappearance rate of ICG (ICG-PDR) was correlated with the liver volume (LV), rrT1 and LVrrT1, providing an MRI-based estimated ICG-PDR value (ICG-PDRest). ResultsSimple linear regression model showed a significant correlation of ICG-PDR with LV (r = 0.32; p = 0.001), T1(post) (r = 0.65; p < 0.001) and rrT1 (r = 0.86; p < 0.001). Assessment of LV and consecutive evaluation of multiple linear regression model revealed a stronger correlation of ICG-PDR with LVrrT1 (r = 0.92; p < 0.001), allowing for the calculation of ICG-PDRest. ConclusionsLiver function as determined using ICG-PDR can be estimated quantitatively from Gd-EOB-DTPA-enhanced MR relaxometry. Volume-assisted MR relaxometry has a stronger correlation with liver function than does MR relaxometry.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PARENCHYMAL ENHANCEMENT; QUANTITATIVE-EVALUATION; CONTRAST AGENT; HEPATIC-UPTAKE; RESECTION; REMNANT; PHASE; FAILURE; RESERVE; Liver function; Magnetic resonance imaging; T1 relaxometry; Indocyanine green clearance; Gd-EOB-DTPA-enhanced imaging |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2019 14:33 |
| Last Modified: | 25 Mar 2019 14:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3211 |
Actions (login required)
 |
View Item |
