Dietl, B. and Marienhagen, J. and Schaefer, C. and Pohl, F. and Murthum, T. and Koelbl, O. (2007) Survival with distant metastatic disease in head and neck cancer. A retrospective analysis. HNO, 55 (10). pp. 785-791. ISSN 0017-6192,
Full text not available from this repository. (Request a copy)Abstract
Questions. The objective of this retrospective analysis was to investigate parameters with a potential impact on survival in a collective of 114 patients with distant metastatic disease after head and neck cancer. Patients and methods. The primary end-point was the survival with distant metastatic disease, the secondary endpoint was overall survival. Primary therapy, local recurrence, second neoplasms, palliative chemotherapy (CHT) and radiotherapy (RT), as well as Karnofsky performance status (KPS) at the time of diagnosis of the metastases were analyzed as potential impact parameters using the log-rank test with subsequent Cox regression analysis. Results. Palliative CHT (P=0.0020) and KPS (P=0.0011) had a significant positive impact on the median survival probability with metastases (8.2 months) using the log-rank test, KPS at the time of diagnosis of metastases remained as an independent prognostic parameter in the Cox regression (P=0.0013). Primary therapy, local tumor control and KPS had a significant positive influence on the median overall survival probability (18.5 months) univariately (P=0.0139, P=0.0106, P=0.0096) and multivariately (P=0.0123, and P=0.0063, P=0.0197, respectively). Conclusions. KPS at the time of diagnosis of metastases is an independent prognostic parameter for both endpoints. Lacking evidence for life prolongation, palliative therapies should therefore first and foremost focus on the stabilization of the KPS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SQUAMOUS-CELL CARCINOMA; QUALITY-OF-LIFE; PHASE-II; OROPHARYNGEAL CARCINOMA; TRANSORAL RESECTION; RADIATION-THERAPY; BONE METASTASES; RECURRENT; CHEMOTHERAPY; CISPLATIN; ENT tumors; distant metastatic disease; local recurrence; second primary; survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Strahlentherapie Medicine > Abteilung für Nuklearmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 09:33 |
| Last Modified: | 01 Dec 2020 09:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32118 |
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