Wagner, Judith and Kaminski, Wolfgang E. and Aslanidis, Charalampos and Moder, Daniel and Hiller, Karl-Anton and Christgau, Michael and Schmitz, Gerd and Schmalz, Gottfried (2007) Prevalence of OPG and IL-1 gene polymorphisms in chronic periodontitis. JOURNAL OF CLINICAL PERIODONTOLOGY, 34 (10). pp. 823-827. ISSN 0303-6979, 1600-051X
Full text not available from this repository.Abstract
Aim: To investigate the association of polymorphisms in the osteoprotegerin (OPG) and interleukin 1 (IL-1) genes with chronic periodontitis (CP). Material and Methods: One hundred and ninety-four individuals (97 CP patients, 97 controls) were genotyped for the OPG polymorphisms Lys3Asn and Met256Val and for the IL-1 polymorphisms IL-1A (-889C/T) and IL-1B (+3953C/T). Results: The homozygous variants coding for Lys3 were present at a higher frequency, whereas Asn3 and Met256 were present at a lower frequency in CP patients/controls (Lys3: 31%/25%, Asn3: 23%/32% and Met256: 66%/73%). Heterozygosity for Lys3Asn was observed at a higher frequency in CP patients/controls (46%/43%). Homozygosity for the Val256 genotype was observed in two CP patients (one in controls). Met256Val heterozygosity was more prevalent in CP patients/controls (32%/20%). All differences were statistically not significant between CP patients and controls. In contrast, both IL-1 polymorphisms were statistically significant. The heterozygous variant for IL-1A was present in 32% of the CP patients and in 20% of the controls (homozygosity (patients/controls) CC: 10%/21% and TT: 55%/33%). Heterozygosity for IL-1B was observed in 37% of the CP patients versus 34% in the controls (homozygosity (patients/controls) CC: 26%/57% and TT: 37%/9%). Conclusions: While the association between the IL-1 polymorphisms and CP was confirmed, no association between the OPG polymorphisms and CP could be found.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GINGIVAL CREVICULAR FLUID; DISEASE PROGRESSION; BRAZILIAN POPULATION; RISK; OSTEOPROTEGERIN; RANKL; IDENTIFICATION; INDIVIDUALS; EXPRESSION; chronic periodontitis; interleukin; interleukin-1A; interleukin-1B; osteoprotegerin; polymorphism |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie > Dr. rer. nat. Karl-Anton Hiller |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 06:59 |
| Last Modified: | 02 Dec 2020 06:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32136 |
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