Galler, K. M. and Yasue, A. and Cavender, A. C. and Bialek, P. and Karsenty, G. and D'Souza, R. N. (2007) A novel role for twist-1 in pulp homeostasis. JOURNAL OF DENTAL RESEARCH, 86 (10). pp. 951-955. ISSN 0022-0345,
Full text not available from this repository. (Request a copy)Abstract
The molecular mechanisms that maintain the equilibrium of odontoblast progenitor cells in dental pulp are unknown. Here we tested whether homeostasis in dental pulp is modulated by Twist-1, a nuclear protein that partners with Runx2 during osteoblast differentiation. Our analysis of Twist-1(+/-) mice revealed phenotypic changes that involved an earlier onset of dentin matrix formation, increased alkaline phosphatase activity, and pulp stones within the pulp. RT-PCR analyses revealed Twist-1 expression in several adult organs, including pulp. Decreased levels of Twist-1 led to higher levels of type I collagen and Dspp gene expression in perivascular cells associated with the pulp stones. In mice heterozygous for both Twist-1 and Runx2 inactivation, the phenotype of pulp stones appeared completely rescued. These findings suggest that Twist-1 plays a key role in restraining odontoblast differ entiation, thus maintaining homeostasis in dental pulp. Furthermore, Twist-1 functions in dental pulp are dependent on its interaction with Runx2.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SAETHRE-CHOTZEN-SYNDROME; STEM-CELLS; PERIODONTAL-LIGAMENT; NEURAL-TUBE; DENTAL-PULP; IN-VIVO; DIFFERENTIATION; EXPRESSION; DENTINOGENESIS; MORPHOGENESIS; Twist-1; Runx2; pulp stones; homeostasis; dental stem cells; odontoblast |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 09:55 |
| Last Modified: | 01 Dec 2020 09:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32139 |
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