Wagenlehner, F. M. E. and Naber, K. G. and Bambl, E. and Raab, U. and Wagenlehner, C. and Kahlau, D. and Hoeller, C. and Witte, W. and Weidner, W. and Lehn, N. and Harbarth, S. and Linde, H. -J. (2007) Management of a large healthcare-associated outbreak of Panton-Valentine leucocidin-positive meticillIn-resistant Staphylococcus aureus in Germany. JOURNAL OF HOSPITAL INFECTION, 67 (2). pp. 114-120. ISSN 0195-6701,
Full text not available from this repository. (Request a copy)Abstract
We report the largest documented healthcare-associated outbreak of Panton-Valentine leucocidin-positive meticillin-resistant Staphylococcus aureus (PVL+ MRSA) in Europe. Six index patients from three long-term care facilities (LTCFs) were screened positive for PVL+ MRSA in 2004 on admission to a community hospital in Germany. The purpose of this prospective study was to describe the prevalence of PVL+ MRSA in the LTCFs before and after infection control interventions. Screening for MRSA with or without PVL was performed in all three LTCFs in 2004 [453 residents, 240 healthcare workers (HCWs)] and 2005 (440 residents, 192 HCWs). Swabs from anterior nares and wounds, if applicable, were collected. Colonised residents and staff were treated with mupirocin nasal ointment and topical antiseptics, and staff were provided with hygiene education. Total MRSA carrier rate of residents and HCWs in 2004 was 11.3% (PVL+ MRSA 9.1%, PVL- MRSA 2.2%). There were comparable carrier rates between residents and HCWs in each LTCF. All PVL+ MRSA isolates were of clonal origin (MLST 22) representing a novel spa sequence type t310. A decrease in total MRSA prevalence (from 11.3 to 5.5%) and PVL+ MRSA (from 9.1 to 3.3%) was observed in 2005. The rate of PVL- MRSA remained unaffected. No symptomatic skin infections were noted among residents or HCWs. In this outbreak incomplete control of PVL+ MRSA presumably resulted from difficult and delayed detection and decolonisation of carriers, incomplete compliance with control measures and tack of enforcement by public health authorities. (C) 2007 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NURSING-HOME; COMMUNITY; TRANSMISSION; INFECTIONS; DISEASE; MRSA; PVL-MRSA; long-term care facility; outbreak; healthcare system |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 09:58 |
| Last Modified: | 01 Dec 2020 09:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32145 |
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