Langguth, Berthold and Wiegand, Rainer and Kharraz, Alexander and Landgrebe, Michael and Marienhagen, Joerg and Frick, Ulrich and Hajak, Goeran and Eichhammer, Peter (2007) Pre-treatment anterior cingulate activity as a predictor of antidepressant response to repetitive transcranial magnetic stimulation (rTMS). NEUROENDOCRINOLOGY LETTERS, 28 (5). pp. 633-638. ISSN 0172-780X,
Full text not available from this repository. (Request a copy)Abstract
OBJECTIVES: Repetitive transcranial magnetic stimulation (rTMS) is a brain stimulation technique which has received increasing attention as an antidepressant treatment. However available studies are characterized by a substantial variability in response. We hypothesized that individual patients characteristics might contribute to such heterogeneity. Therefore we investigated whether either alterations of regional cerebral blood flow (rCBF) or clinical characteristics may predict antidepressant response to rTMS. DESIGN: 24 patients with major depression and stable medication received high frequency (10 Hz) rTMS over the left dorsolateral prefrontal cortex (DLPFC) for two weeks as add-on treatment. ECD-Single photon emission computed tomographay (SPECT) imaging was performed I to 2 days before rTMS. SETTING: Tertial referral center RESULTS: After two weeks of rTMS a mean reduction of 30% of the initial Hamilton Depression Rating Score (HAMD) was observed. Using a multivariate regression model with simultaneous evaluation of the relative impact of a-priori chosen potential factors influencing treatment outcome, two variables, the pretreatment anterior cingulate rCBF and the former response to antidepressant agents proved significant. High pretreatment anterior cingulate activity and low treatment resistance to pharmacologic therapy were positive predictors for treatment response to rTMS. CONCLUSIONS: Pretreatment anterior cingulate activity seems to be a useful prognostic marker of rTMS treatment response, which is in line with other treatment strategies, like sleep deprivation, electroconvulsive therapy or antidepressant medication.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CEREBRAL-BLOOD-FLOW; DORSOLATERAL PREFRONTAL CORTEX; LOW-FREQUENCY RTMS; MAJOR DEPRESSION; ELECTROCONVULSIVE-THERAPY; FUNCTIONAL CONNECTIVITY; FRONTAL-CORTEX; DOUBLE-BLIND; BRAIN; TMS; repetitive transcranial magnetic stimulation; major depression; predictor; functional imaging; single photon emission computed tomography; SPECT; treatment resistance |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Medicine > Abteilung für Nuklearmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 10:33 |
| Last Modified: | 01 Dec 2020 10:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32168 |
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