Schweda, Frank and Friis, Ulla and Wagner, Charlotte and Skott, Ole and Kurtz, Armin (2007) Renin release. PHYSIOLOGY, 22 (5). pp. 310-319. ISSN 1548-9213, 1548-9221
Full text not available from this repository. (Request a copy)Abstract
The aspartyl-protease renin is the key regulator of the renin- angiotensin- aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so- called juxtaglomerular epithelioid cells, located in the walls of renal afferent arterioles at the entrance of the glomerular capillary network. It has been known for a long time that renin synthesis and secretion are stimulated by the sympathetic nerves and the prostaglandins and are inhibited in negative feedback loops by angiotensin II, high blood pressure, salt, and volume overload. In contrast, the events controlling the function of renin- secreting cells at the organ and cellular level are markedly less clear and remain mysterious in certain aspects. The unravelling of these mysteries has led to new and interesting insights into the process of renin release.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RAT JUXTAGLOMERULAR CELLS; SMOOTH-MUSCLE-CELLS; AFFERENT GLOMERULAR ARTERIOLE; ISOLATED-PERFUSED KIDNEY; CYCLIC-AMP; SECRETORY GRANULES; MESSENGER-RNA; NITRIC-OXIDE; TUBULOGLOMERULAR FEEDBACK; INTRACELLULAR CALCIUM; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda |
| Depositing User: | Petra Gürster |
| Date Deposited: | 04 Dec 2020 08:10 |
| Last Modified: | 04 Dec 2020 08:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32183 |
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