Schulte-Mattler, Wilhelm J. and Opatz, Oliver and Blersch, Wendelin and May, Ame and Bigalke, Hans and Wohlfahrt, Kai (2007) Botulinum toxin A does not alter capsaicin-induced pain perception in human skin. JOURNAL OF THE NEUROLOGICAL SCIENCES, 260 (1-2). pp. 38-42. ISSN 0022-510X,
Full text not available from this repository. (Request a copy)Abstract
A genuine peripheral antinociceptive and anti-inflammatory effect of Botulinum neurotoxin type A (BoNT/A) has been proposed but could not be demonstrated in humans so far. Therefore, 100 mouse units of Botulinum toxin A (Dysport(R)) and placebo were injected in a double blind paradigm in defined skin areas of 50 subjects. At baseline and after 4 and 8 weeks allodynia was induced in the skin areas with capsaicin ointment. Heat and cold pain threshold temperatures were measured with quantitative sensory testing, and threshold intensities upon electrical stimulation with a pain specific surface electrode were determined. No BoNT/A related differences in pain perception were found at any quality. There is neither a direct peripheral antinociceptive effect nor a significant effect against neurogenic inflammation of BoNT/A in humans. (C) 2007 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DOUBLE-BLIND; HYPERALGESIA; NEUROTOXINS; NOCICEPTION; RELEASE; MUSCLES; botulinum toxin; capsaicin; inflammation; nociception; quantitative sensory testing; thermal pain |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 07:20 |
| Last Modified: | 01 Dec 2020 07:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32205 |
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