Soellner, Liane and M, Shaqireen Kwajah M. and Wu, Ju Ting and Schwarz, Herbert (2007) Signal transduction mechanisms of CD137 ligand in human monocytes. CELLULAR SIGNALLING, 19 (9). pp. 1899-1908. ISSN 0898-6568, 1873-3913
Full text not available from this repository. (Request a copy)Abstract
Bidirectional signalling, i.e. simultaneous signalling through a receptor as well as its cell surface-bound ligand has been identified for several members of the TNF and TNF receptor family members. Reverse signalling through the ligands offers the advantage of an immediate feed-back and a more precise fine tuning of biological responses. Little is known about the molecular nature of reverse signalling through the ligands. CD137 ligand, member of the TNT family is expressed on monocytes and induces activation, migration, prolongation of survival and proliferation of monocytes. Here we show that reverse signalling by CD137 ligand is mediated by protein tyrosine kinases, p38 mitogen activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK)1,2, MAP/ERK kinase (MEK), Phosphoinositide-3-kinase (P13-K) and protein kinase A (PKA) but not by protein kinase C (PKC). This study also shows that reverse signalling relies on the same signal transduction molecules as signalling through classical receptors and is in its nature not different from it. (c) 2007 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN-KINASE-C; NERVE GROWTH-FACTOR; RECEPTOR FAMILY; TYROSINE KINASE; IN-VITRO; ACTIVATION; CELLS; REVERSE; PROLIFERATION; INHIBITOR; human; CD137 ligand; monocytes; signalling; signal transduction |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 08:46 |
| Last Modified: | 01 Dec 2020 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32232 |
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