Grassel, Susanne and Ahmed, Nazish (2007) Influence of cellular microenvironment and paracrine signals on chondrogenic differentiation. FRONTIERS IN BIOSCIENCE, 12. pp. 4946-4956. ISSN 1093-9946,
Full text not available from this repository. (Request a copy)Abstract
Articular cartilage disorders and injuries often result in life long chronic pain and compromised quality of life, thus regeneration of articular cartilage is a persistent challenge to medical science. One of the most promising therapeutic approaches is cell based tissue engineering which provides a healthy population of cells to the injured site and requires differentiated chondrocytes from the uninjured site as base material. Use of healthy chondrocytes has several limitations and an excellent alternative cell population could be adult marrow stromal cells/mesenchymal stem cells (MSCs) which are known to possess extensive proliferation potential and proven capability to differentiate into chondrocytes. Both, in vivo and in vitro pliability of MSCs and chondrocytes greatly depends on their microenvironment. Gene and protein expression profiles of both the cell types can be altered by soluble factors from surrounding tissue/cells or by direct cellular contact. For MSC or chondrocyte-based cartilage repair, inhibition of hypertrophy and stabilization of the cartilaginous phenotype in the implant is a prerequisite for success and long lasting vitality of the repaired tissue.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESENCHYMAL STEM-CELLS; ENDOTHELIAL GROWTH-FACTOR; SUBCHONDRAL VASCULAR SYSTEM; MARROW STROMAL CELLS; C-TERMINAL DOMAIN; BONE-MARROW; ARTICULAR-CARTILAGE; IN-VITRO; CHONDROCYTE DIFFERENTIATION; OSTEOARTHRITIC CHONDROCYTES; mesenchymal stem cells; chondroprogenitor cells; chondrocytes; articular cartilage; microenvironment; regulatory factors; coculture; review |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 12:06 |
| Last Modified: | 01 Dec 2020 12:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32279 |
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