Maennel, Daniela N. (2007) Advances in sepsis research derived from animal models. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 297 (5). pp. 393-400. ISSN 1438-4221,
Full text not available from this repository. (Request a copy)Abstract
Inflammation is the basic process by which tissues of the body respond to infection. Activation of the immune system normally leads to removal of microbial pathogens, and after resolution of the inflammation immune homeostasis is restored. This controlled process, however, can be disturbed resulting in disease. Therefore, many Studies using infection models have investigated the participating immune mechanisms aiming at possible therapeutic interventions. Defined model substances such as bacterial lipopolysaccharide (endotoxin) have been used to mimic bacterial infections and analyze their immune stimulating functions. A complex network of molecular mechanisms involved in the recognition and activation processes of bacterial infections and their regulation has developed from these studies. More complex infection models will now help to interpret earlier observations leading to the design of relevant new infection models. (c) 2007 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TOLL-LIKE RECEPTORS; NECROSIS-FACTOR-ALPHA; INNATE-IMMUNE-SYSTEM; NEGATIVE REGULATOR; INFLAMMATORY RESPONSE; SEPTIC PERITONITIS; GAMMA-INTERFERON; CROSS-TOLERANCE; DEFICIENT MICE; PROTECTS MICE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Dec 2020 11:04 |
| Last Modified: | 03 Dec 2020 11:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32287 |
Actions (login required)
 |
View Item |
