Ewing, Patricia and Hildebrandt, Gerhard C. and Planke, Simone and Andreesen, Reinhard and Holler, Ernst and Gerbitz, Armin (2007) Cobalt protoporphyrine IX-mediated heme oxygenase-I induction alters the inflammatory cytokine response, but not antigen presentation after experimental allogeneic bone marrow transplantation. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 20 (3). pp. 301-308. ISSN 1107-3756,
Full text not available from this repository. (Request a copy)Abstract
Acute graft-versus-host disease (aGvHD) remains the major cause of mortality after allogeneic stem cell transplantation. Acute GvHD can be partially prevented when heme oxygenase- 1 (HO- 1) is induced in the recipient prior to transplantation but the mechanisms are not fully understood. Using a murine haploidentical bone marrow transplantation (BMT) model (C57B1/6 -> B6D2F1) we tested whether HO-I induction altered the alloreactive T cell response or rather modulated the inflammatory cytokine profile early after BMT. In vivo administration of cobalt protoporphyrine IX (CoPP) did not affect the expression of MHC class I and 11 or the costimulatory molecules CD80 and CD86 on murine peritoneal and on splenic dendritic cells (DCs). Allospecific T cell proliferation and interferon gamma secretion did not differ in mixed lymphocyte reactions using either CoPP-pretreated allogeneic recipients or control-treated DCs as stimulators. Furthermore, splenic DCs, isolated one to four days after BMT from CoPP-pretreated recipients did not show any differences in the expression of costimulatory molecules compared to untreated controls, and T cell expansion and the cytolytic capacity 14 days after BMT were equal in the control and CoPP-treated allogeneic groups. Serum tumor necrosis factor a levels were significantly reduced in CoPP-treated allogeneic recipients when compared to allogeneic
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; CARBON-MONOXIDE; PRESENTING CELLS; DENDRITIC CELLS; EXPRESSION; APOPTOSIS; SURVIVAL; MICE; PATHOPHYSIOLOGY; DYSREGULATION; allogeneic bone marrow transplantation; heme oxygenase-1; cobalt protoporphyrine; antigen presenting cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 11:17 |
| Last Modified: | 02 Dec 2020 11:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32288 |
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