Sedlacek, Kamil and Neureuther, Katharina and Mueller, Jakob C. and Stark, Klaus and Fischer, Marcus and Baessler, Andrea and Reinhard, Wibke and Broeckel, Ulrich and Lieb, Wolfgang and Erdmann, Jeanette and Schunkert, Heribert and Riegger, Guenter and Illig, Thomas and Meitinger, Thomas and Hengstenberg, Christian (2007) Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations. JOURNAL OF MOLECULAR MEDICINE-JMM, 85 (9). pp. 997-1004. ISSN 0946-2716,
Full text not available from this repository. (Request a copy)Abstract
Recent data provided strong evidence for the association of single nucleotide polymorphisms (SNPs) in the lymphotoxin-alpha (LTA) and galectin-2 (LGALS2) genes with myocardial infarction (MI) in a Japanese population. For populations of other genetic background, the relevance of these polymorphisms in the pathogenesis of MI remains controversial. We aimed to define the role of LTA and LGALS2 SNPs in two German MI populations with markedly different ascertainment strategies. Two different MI populations were studied. In the first population, MI patients were ascertained by a strong family history of MI (n=1214). Controls were unrelated disease-free participants of the study (n=1080). The second population included patients suffering from sporadic (nonfamilial) MI from the German KORA register (n=607). The control group consisted of participants of the WHO MONICA survey in Germany (n=1492). TaqMan assays were used to determine the genotypes of 4 SNPs in the LTA genomic region and 1 SNP in the LGALS2 gene. Single SNPs in both genomic regions as well as haplotypes in the LTA genomic region were tested for association in various models of inheritance. No association with MI could be found for any of the examined SNPs in the LTA genomic region and LGALS2 gene, or for haplotypes spanning the LTA genomic region. In two MI populations of European descent with markedly different ascertainment strategies, we were not able to identify a significant association of SNPs in the LTA genomic region or the LGALS2 gene with MI. These variants are unlikely to play a significant role in populations of European origin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONARY-HEART-DISEASE; LINKAGE DISEQUILIBRIUM PATTERNS; MONICA PROJECT; RISK-FACTORS; EVENT RATES; GENE; POLYMORPHISMS; HAPLOTYPES; SUSCEPTIBILITY; JAPANESE; genetics; lymphotoxin-alpha; galectin-2; myocardial infarction; coronary artery disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 12:40 |
| Last Modified: | 01 Dec 2020 12:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32299 |
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