Schaeffler, A. and Schoelmerich, J. and Salzberger, B. (2007) Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs. TRENDS IN IMMUNOLOGY, 28 (9). pp. 393-399. ISSN 1471-4906, 1471-4981
Full text not available from this repository. (Request a copy)Abstract
Adipose tissue has long been regarded as a mostly resting tissue that is dedicated solely to energy storage and release. However, in recent years, this view has changed dramatically following new insights into the metabolic and immunological functions of preadipocytes and adipocytes. There are several lines of evidence for the involvement of adipose tissue in innate and acquired immune responses. First, adipocytes are potent producers of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor (TNF), and chemokines. Furthermore, adipocytes secrete high amounts of adipokines, such as leptin, adiponectin and resistin, that regulate monocyte/macrophage function, and also secrete molecules associated with the innate immune system, such as the ClqTNF-related protein superfamily. Finally, preadipocytes and adipocytes express a broad spectrum of functional Toll-like receptors and the former can convert into macrophage-like cells. Collectively, these data clearly establish the role of adipose tissue as a new member of the immune system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; MONOCYTE CHEMOATTRACTANT PROTEIN-1; REPEAT-CONTAINING SEQUENCE; INSULIN-RESISTANCE; COLLAGENOUS REPEAT; CROHNS-DISEASE; CREEPING FAT; FACTOR-ALPHA; CHROMOSOMAL LOCALIZATION; GENOMIC ORGANIZATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 01 Dec 2020 10:50 |
| Last Modified: | 01 Dec 2020 10:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32344 |
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