Teml, Alexander and Schwab, Matthias and Hommes, Daan W. and Almer, Sven and Lukas, Milan and Feichtenschlager, Thomas and Florin, Timothy and Seiderer, Julia and Petritsch, Wolfgang and Bokemeyer, Bernd and Kreisel, Wolfgang and Herrlinger, Klaus R. and Knoflach, Peter and Bonaz, Bruno and Klugmann, Thomas and Herfarth, Hans and Pedarnig, Nikolaus and Reinisch, Walter (2007) A systematic survey evaluating 6-thioguanine-related hepatotoxicity in patients with inflammatory bowel disease. WIENER KLINISCHE WOCHENSCHRIFT, 119 (17-18). pp. 519-526. ISSN 0043-5325, 1613-7671
Full text not available from this repository. (Request a copy)Abstract
OBJECTIVE: Drug-induced liver injury was recently reported as a major complication leading to hepatic nodular regenerative hyperplasia (NRH) in patients with inflammatory bowel disease (IBD) and 6-thioguanine (6-TG) therapy. The aim of the study was to evaluate the prevalence of 6-TG-related hepatotoxicity in a large multi-centered IBD population by means of a systematic online survey. METHODS: Clinical and laboratory data, imaging techniques (sonography, CT, MRI) and histology of liver biopsies were surveyed in IBD patients treated with 6-TG. The decision on whether liver imaging and/or liver biopsy were performed was exclusively at the discretion of the investigator. RESULTS: 6-TG use was fully documented in 296 patients (median treatment duration 56 weeks, range < 1-207). Laboratory signs of drug-induced liver injury were found in 43 patients (14.5%). Liver imaging revealed pathologic results in 68/176 patients (38.6%). Liver biopsy was performed in a subset of 60 patients; using silver-reticulin staining (n = 59), NRH was considered in 16 patients (27.1%). Age was the only independent, albeit weak, risk factor for development of NRH. CONCLUSION: This large online survey confirms the strong association between 6-TG treatment and the significant risk of development of NRH in patients with IBD. The definitive diagnosis of NRH depends solely upon liver biopsy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NODULAR REGENERATIVE HYPERPLASIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; VENO-OCCLUSIVE DISEASE; ACTIVE CROHNS-DISEASE; IBD PATIENTS; MYELOID-LEUKEMIA; LONG-TERM; THIOGUANINE; THERAPY; LIVER; 6-thioguanine; drug-induced liver injury; inflammatory bowel disease; nodular regenerative hyperplasia; thiopurines |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 13:42 |
| Last Modified: | 01 Dec 2020 13:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32354 |
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