Haubner, Frank and Lehle, Karla and Muenzel, Daniela and Schmid, Christof and Birnbaum, Dietrich E. and Preuner, Juergen G. (2007) Hyperglycemia increases the levels of vascular cellular adhesion molecule-1 and monocyte-chemoattractant-protein-1 in the diabetic endothelial cell. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 360 (3). pp. 560-565. ISSN 0006-291X,
Full text not available from this repository. (Request a copy)Abstract
Hyperglycemia is the major cause of diabetic angiopathy. Aim of our study was to evaluate the impact of high glucose on cell growth and function of human "diabetic" endothelial cells (EC). Incubation of non-diabetic EC with glucose moderately inhibited cell growth and increased the expression of ICAM-1 and E-selectin. In the disease-specific EC, glucose treatment resulted also in moderately inhibited cell growth by 5-10%, increased basal expression of VCAM-1 by 10-20%, and an enhanced release of monocyte-chemoattractant-protein-1 (MCP-1) by 40-70%. The expression of ICAM-1 and E-selectin and the release of IL-6 and IL-8 was not affected. The usage of our disease-specific EC model might evaluate the impact of systemic factors of diabetic patients in the progression of endothelial dysfunction, and may be suitable to develop relevant therapeutic regimens. (c) 2007 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIGH GLUCOSE-CONCENTRATIONS; E-SELECTIN; MICROVASCULAR COMPLICATIONS; SURFACE EXPRESSION; FAS LIGAND; IN-VITRO; MELLITUS; ICAM-1; ATHEROSCLEROSIS; ACTIVATION; endothelial cell; diabetes mellitus; glucose; cell growth; adhesion molecules; cytokines |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 10:29 |
| Last Modified: | 02 Dec 2020 10:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32367 |
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