Bruennler, T. and Mandraka, F. and Zierhut, S. and Siebig, S. and Wrede, C. and Klebl, F. and Holler, E. and Salzberger, B. and Schoelmerich, J. and Langgartner, J. (2007) Outcome of hemato-oncologic patients with and without stem cell transplantation in a medical ICU. EUROPEAN JOURNAL OF MEDICAL RESEARCH, 12 (8). pp. 323-330. ISSN 0949-2321,
Full text not available from this repository. (Request a copy)Abstract
Objective: To assess the outcome of a mixed population of critical ill patients with haematological malignancies with special focus on the comparison of patients who underwent stem cell transplantation with non-transplanted patients. Methods: Retrospective, unicentric analysis of 94 critical ill cancer patients in a tertiary care centre in a period of two years time. Results: We analysed different variables at admission as well as different treatment modalities during the ICU stay. We compared the outcome by using chi-square test by Pearson for categorical variables and Kaplan-Meier as well as Cox-Regression for survival analysis. The general patients characteristics did not significantly differ between transplanted and nontransplanted patients. The overall ICU and hospital mortality were 43% and 54%. Considering just patients with mechanical ventilation we found ICU and hospital mortalities of 65% and 82% in the stem cell transplantation group vs. 67% and 74% in the nontransplanted group, respectively. As risk factors for overall mortality in multivariate analysis only the Simplified Acute Physiology Scale 11 and the need of ventilation remained significant. Between the underlying diseases mortality did not show significant differences at all. Conclusions: The outcome and prognosis of critical ill cancer patients has generally slightly improved over the last years. Our data show no statistically significant differences regarding outcome and prognosis between stem cell transplanted and non-transplanted patients receiving ICU treatment. A stem cell transplantation should not be considered a strong contraindication for ICU treatment or artificial ventilation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTENSIVE-CARE-UNIT; BONE-MARROW-TRANSPLANTATION; REQUIRING MECHANICAL VENTILATION; ACUTE RESPIRATORY-FAILURE; ILL CANCER-PATIENTS; HEMATOLOGICAL MALIGNANCY; PROGNOSTIC-FACTORS; NEUTROPENIC PATIENTS; SURVIVAL; ADMISSION; hematologic malignancy; stem cell transplantation; critical care; intensive care unit; outcome; mortality |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 14:00 |
| Last Modified: | 01 Dec 2020 14:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32383 |
Actions (login required)
 |
View Item |
