Pfister, Karin and Radons, Juergen and Busch, Raymonde and Tidball, James G. and Pfeifer, Michael and Freitag, Lutz and Feldmann, Horst-Juergen and Milani, Valeria and Issels, Rolf and Multhoff, Gabriele (2007) Patient survival by Hsp70 membrane phenotype - Association with different routes of metastasis. CANCER, 110 (4). pp. 926-935. ISSN 0008-543X, 1097-0142
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND. Heat shock proteins (HSPs) play important roles in tumor immunity. The authors prospectively investigated the correlation between the tumor-specific Hsp70 membrane expression as an independent clinicopathological marker and overall survival in tumor entities that differ in their route of metastasis. METHODS. Hsp70 membrane expression was examined by flow cytometry in 58 colon, 19 gastric, 54 lower rectal carcinoma, and 19 squamous cell carcinoma specimens and the corresponding normal tissues at time of first diagnosis. Kaplan-Meier survival curves were analyzed to determine the relation of Hsp70 expression to the patients' prognosis. RESULTS. An Hsp70 membrane-positive phenotype was found in 40% (colon), 137% (gastric), 43% (lower rectal), and 42% (squamous cell) of the analyzed tumor specimens. None of the corresponding normal tissues was found to be Hsp70 membrane-positive. In patients with colon (P = .032) and gastric (P = .045) carcinomas, an Hsp70 membrane expression correlated significantly with an improved overall survival; a negative association was seen in lower rectal (P = .085) and squamous cell carcinoma (P = .048). CONCLUSIONS. The authors hypothesized that differing relations between surface expression of Hsp70 on tumor cells and clinical outcomes may reflect differences in the route of metastases. Colon and gastric carcinomas metastasize into the liver where hepatic natural killer cells may have the capacity to recognize and kill Hsp70 membrane- positive tumor cells and thus account for a better overall survival.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NATURAL-KILLER-CELLS; HEAT-SHOCK-PROTEIN; SEVERE COMBINED IMMUNODEFICIENCY; BOUND HEAT-SHOCK-PROTEIN-70 HSP70; ACUTE MYELOID-LEUKEMIA; CYTOLYTIC ACTIVITY; TUMOR-CELLS; NK CELLS; COLORECTAL-CANCER; EXPRESSION; Hsp70; clinical trial; prognostic marker; overall survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 14:06 |
| Last Modified: | 01 Dec 2020 14:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32386 |
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