Sigruener, Alexander and Buechler, Christa and Bared, Salim Maa and Grandl, Margot and Aslanidis, Charalampos and Ugocsai, Peter and Gehrmann, Mathias and Schmitz, Gerd (2007) E-LDL upregulates TOSO expression and enhances the survival of human macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 359 (3). pp. 723-728. ISSN 0006-291X,
Full text not available from this repository. (Request a copy)Abstract
Uptake of modified lipoproteins by macrophages causes foam cell formation and promotes atherosclerosis. Atherogenic lipoproteins are cytotoxic and induce cell death under certain conditions but may also enhance macrophage survival. Macrophages treated with enzymatically modified LDL (E-LDL) were subjected to GeneChip analysis and the antiapoptotic gene TOSO was found induced. TOSO mRNA is upregulated and apoptosis is reduced in E-LDL but not in oxidized LDL (Ox-LDL) loaded macrophages. FLIPL abundance was suggested to mediate the antiapoptotic properties of TOSO; however, FLIPL was not changed. Ox-LDL is internalized predominantly by scavenger receptors such as CD36 while E-LDL particles are preferentially internalized by Fc- and complement-receptor dependent phagocytosis and internalization of phagobeads by macrophages upregulates TOSO. In COS-7 cells however, phagocytotic activity was not affected by TOSO. These data indicate that E-LDL-generated foam cells are protected from cell death most likely through the expression of TOSO by a FLIPL independent mechanism. (c) 2007 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOW-DENSITY-LIPOPROTEIN; ENZYMATICALLY DEGRADED LDL; HUMAN BLOOD MONOCYTES; OXIDIZED LDL; INDUCED APOPTOSIS; DNA-SYNTHESIS; CELL-SURFACE; DEATH DOMAIN; PROTEIN; ATHEROGENESIS; TOSO; E-LDL; Ox-LDL; macrophages; apoptosis; phagocytosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 14:28 |
| Last Modified: | 01 Dec 2020 14:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32397 |
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