Samani, Nilesh J. and Erdmann, Jeanette and Hall, Alistair S. and Hengstenberg, Christian and Mangino, Massimo and Mayer, Bjoern and Dixon, Richard J. and Meitinger, Thomas and Braund, Peter and Wichmann, H.-Erich and Barrett, Jennifer H. and Koenig, Inke R. and Stevens, Suzanne E. and Szymczak, Silke and Tregouet, David-Alexandre and Iles, Mark M. and Pahlke, Friedrich and Pollard, Helen and Lieb, Wolfgang and Cambien, Francois and Fischer, Marcus and Ouwehand, Willem and Blankenberg, Stefan and Balmforth, Anthony J. and Baessler, Andrea and Ball, Stephen G. and Strom, Tim M. and Braenne, Ingrid and Gieger, Christian and Deloukas, Panos and Tobin, Martin D. and Ziegler, Andreas and Thompson, John R. and Schunkert, Heribert (2007) Genomewide association analysis of coronary artery disease. NEW ENGLAND JOURNAL OF MEDICINE, 357 (5). pp. 443-453. ISSN 0028-4793, 1533-4406
Full text not available from this repository. (Request a copy)Abstract
Background Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease. Methods We first identified chromosomal loci that were strongly associated with coronary artery disease in the Wellcome Trust Case Control Consortium (WTCCC) study (which involved 1926 case subjects with coronary artery disease and 2938 controls) and looked for replication in the German MI [Myocardial Infarction] Family Study (which involved 875 case subjects with myocardial infarction and 1644 controls). Data on other single-nucleotide polymorphisms (SNPs) that were significantly associated with coronary artery disease in either study (P<0.001) were then combined to identify additional loci with a high probability of true association. Genotyping in both studies was performed with the use of the GeneChip Human Mapping 500K Array Set (Affymetrix). Results Of thousands of chromosomal loci studied, the same locus had the strongest association with coronary artery disease in both the WTCCC and the German studies: chromosome 9p21.3 (SNP, rs1333049) (P=1.80x10(-14) and P=3.40x10(-6), respectively). Overall, the WTCCC study revealed nine loci that were strongly associated with coronary artery disease (P<1.2x10(-5) and less than a 50% chance of being falsely positive). In addition to chromosome 9p21.3, two of these loci were successfully replicated (adjusted P<0.05) in the German study: chromosome 6q25.1 (rs6922269) and chromosome 2q36.3 (rs2943634). The combined analysis of the two studies identified four additional loci significantly associated with coronary artery disease (P<1.3x10(-6)) and a high probability(>80%) of a true association: chromosomes 1p13.3 (rs599839), 1q41 (rs17465637), 10q11.21 (rs501120), and 15q22.33 (rs17228212). Conclusions We identified several genetic loci that, individually and in aggregate, substantially affect the risk of development of coronary artery disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MITOCHONDRIAL C-1-TETRAHYDROFOLATE SYNTHASE; WIDE ASSOCIATION; RISK-FACTORS; MYOCARDIAL-INFARCTION; GENE; SUSCEPTIBILITY; REPLICATION; EXPRESSION; FAMILIES; LINKAGE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Dec 2020 07:38 |
| Last Modified: | 11 Jan 2021 08:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32402 |
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