Kaufmann, Doris and Pojarova, Michaela and Vogel, Susanne and Liebl, Renate and Gastpar, Robert and Gross, Dietmar and Nishino, Tsuyuki and Pfaller, Tobias and von Angerer, Erwin (2007) Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY, 15 (15). pp. 5122-5136. ISSN 0968-0896, 1464-3391
Full text not available from this repository. (Request a copy)Abstract
Small molecules such as indoles are attractive as inhibitors of tubulin polymerization. Thus a number of 2-phenylindole-3-carbaldehydes with lipophilic substituents in both aromatic rings was synthesized and evaluated for antitumor activity in MDA-MB 231 and MCF-7 breast cancer cells. Some 5-alkylindole derivatives with a 4-methoxy group in the 2-phenyl ring strongly inhibit the growth of breast cancer cells with IC50 values of 5-20 nM. Their action can be rationalized by the cell cycle arrest in G(2)/M phase due to the inhibition of tubulin polymerization. (c) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COMBRETASTATIN A-4 ANALOGS; POTENT ANTITUBULIN AGENTS; TUBULIN POLYMERIZATION; BIOLOGICAL EVALUATION; IN-VIVO; INHIBITORS; INDOLE; ARYLTHIOINDOLES; 3-AROYLINDOLES; DERIVATIVES; phenylindoles; breast cancer; tubulin polymerization; cell cycle arrest |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 13:44 |
| Last Modified: | 02 Dec 2020 13:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32415 |
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