Pina, Ana Luisa and Kubitza, Marion and Brawanski, Alexander and Tombran-Tink, Joyce and Kloth, Sabine (2007) Expression of pigment-epithelium-derived factor during kidney development and aging. CELL AND TISSUE RESEARCH, 329 (2). pp. 329-338. ISSN 0302-766X, 1432-0878
Full text not available from this repository. (Request a copy)Abstract
Inhibitors and stimulators of endothelial cell growth are essential for the coordination of blood vessel formation during organ growth and development. In the adult kidney, one of the major inhibitors of angiogenesis is pigment-epithelium-derived factor (PEDF). We have analyzed the expression and distribution of PEDF during various stages of renal development and aging with particular emphasis on the formation of functional glomeruli. We show that PEDF gene expression and protein levels in the kidney significantly increase with age. We have detected PEDF in the mesenchyme and endothelial cells at all developmental stages studied, in all regions of the nephrogenic zone in which the formation of new blood vessels is associated with the development of nephrons and collecting ducts, and in mature podocytes in the adult kidney. Our results are the first to suggest that PEDF is important in early renal postnatal development, that it could be relevant to the maturation of glomerular function and the filtration barrier formed by these cells, and that it may serve as an anti-angiogenic modulator during kidney development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INHIBITS CHOROIDAL NEOVASCULARIZATION; ENDOTHELIAL GROWTH-FACTOR; FACTOR PEDF; VEGF-A; ESSENTIAL MOLECULE; MOUSE KIDNEY; ANGIOGENESIS; VASCULATURE; PODOCYTE; SITE; pigment-epithelium-derived factor; kidney development and aging; podocytes; glomeruli; nephrons; endothelial cells; anti-angiogenic factors; rat (Long Evans) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 06:49 |
| Last Modified: | 02 Dec 2020 06:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32421 |
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