Englert, Carsten and Fierlbeck, Johann and von Glasser, Sabine Schulz and Nerlich, Michael and Hammer, Joachim (2007) Mechanical characteristics of articular cartilage bonds. CLINICAL BIOMECHANICS, 22 (7). pp. 849-855. ISSN 0268-0033,
Full text not available from this repository. (Request a copy)Abstract
Background Sutures for adaptation of articular cartilage are used in arthritis therapy techniques. However, little is known about the mechanical functionality of these sutures. The objective of the present work was to compare the mechanical properties of articular cartilage bonds either generated by suture, or, alternatively, by chemical cross-linking of the opposing surfaces or in vitro integrative repair of cartilage blocks. Methods. Bonding was achieved by suture in varying numbers, positions and orientations, by surface cross-linking using carbodiimide in combination with pepsin or guanidine (immediate bonding), or by cultivation for 14 days, either with or without testosterone. The mechanical properties of the cartilage bonds were measured under tensile loading. Findings. Suture led to the highest maximal load at failure and by far to the highest strain and lowest stiffness of the bonded samples. Immediate bonding by chemical cross-linking in combination with pepsin led to a low force at failure, but the highest stiffness, as compared to all other groups. Cultivation in the presence of testosterone led to a higher force at failure and a higher strain than chemical cross-linking. Interpretation. Suture technique for bonding of cartilage surfaces leads to a very elastic adaptation which allows synovial fluid flow in between the interface of cartilage wounds. Long-term bonding of cartilage wounds would be counteracted by a fluid flow through the interface during motion of the joint. Immediate bonding of cartilage wounds by chemical cross-linking reagents might be a useful alternative tool. Even more promising, with regard to the mechanical properties, appears to be integrative repair of cartilage blocks stimulated by testosterone. (c) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADHESIVE STRENGTH; FIBRIN GLUE; IN-VITRO; REPAIR; INTEGRATION; INHIBITION; articular cartilage; cartilage repair; minimally invasive surgical procedure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 07:00 |
| Last Modified: | 02 Dec 2020 07:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32427 |
Actions (login required)
 |
View Item |
