Broeckel, Ulrich and Hengstenberg, Christian and Mayer, Bjoern and Maresso, Karen and Gaudet, Daniel and Seda, Ondrej and Tremblay, Johanne and Holmer, Stephan and Erdmann, Jeanette and Gloeckner, Christian and Harrison, Michael and Martin, Lisa J. and Williams, Jeff T. and Schmitz, Gerd and Riegger, Guenter A. J. and Jacob, Howard J. and Hamet, Pavel and Schunkert, Heribert (2007) A locus on chromosome 10 influences C-reactive protein levels in two independent populations. HUMAN GENETICS, 122 (1). pp. 95-102. ISSN 0340-6717,
Full text not available from this repository. (Request a copy)Abstract
High sensitivity C-reactive protein (hsCRP) is an independent risk factor for cardiovascular disease, such as stroke or coronary artery disease. Genetic factors influence significantly the inter-individual variability of hsCRP. The aim of this study was to identify genomic regions influencing hsCRP levels. A genome scan was performed in two independent studies of Caucasian populations, namely 513 Western-European families ascertained for myocardial infarction (n = 1,406) and 120 French-Canadian families diagnosed with hypertension (n = 758). In the myocardial infarction families, 31% of the inter-individual variation of hsCRP levels was explained by genetic factors (P = 0.0000015) and loci influencing hsCRP were identified on chromosomes 10 (at 141 cM) and 5 (at 150 cM) with multipoint LOD scores of 3.15 and 2.23, respectively. An additional suggestive signal was detected on chromosome 2 in subset analyses. A similar degree of heritability has been observed in a second independent population of French-Canadian hypertensive families for hsCRP (30%) and linkage results for chromosome 10 were confirmed with maximum LOD score of 2.7. We identified a chromosomal region in two independent populations which influences hsCRP in addition to several unique regions. This provides targets for the identification of genes involved in the regulation of hsCRP and the development and progression of vascular disease, including stroke.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; LINKAGE ANALYSIS; ISCHEMIC-STROKE; STATIN THERAPY; CRP LEVELS; INFLAMMATION; POLYMORPHISM; GENE; RISK; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 07:12 |
| Last Modified: | 11 Jan 2021 08:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32445 |
Actions (login required)
 |
View Item |
