Christgau, Michael and Caffesse, Raul G. and Schmalz, Gottfried and D'Souza, Rena N. (2007) Extracellular matrix expression and periodontal wound-healing dynamics following guided tissue regeneration therapy in canine furcation defects. JOURNAL OF CLINICAL PERIODONTOLOGY, 34 (8). pp. 691-708. ISSN 0303-6979, 1600-051X
Full text not available from this repository. (Request a copy)Abstract
Aim: Temporal and spatial expression pattern of extracellular matrix (ECM) components in furcation defects following guided tissue regeneration (GTR) compared with open-flap debridement (OFD). Material and Methods: In 21 dogs, mandibular second and fourth pre-molars were treated with one non-resorbable and three different resorbable membranes. Third pre-molars were treated by OFD. After 2, 4, 8 weeks and 3, 6, and 12 months, tissues were analysed by immunohistochemistry for collagen I (Col-I) and III (Col-III), fibronectin (FN), bone sialoprotein (BSP), and osteopontin (OPN). Results: At 2 weeks, the defect was mainly occupied by FN+ granulation tissue (GT), which was sequentially replaced by new connective tissue expressing FN, Col-I, and increasingly Col-III. Following superficial resorptions by OPN+ osteoclasts and odontoclasts, cementum and bone formation ensued with strong expression of BSP and OPN along bone and tooth surfaces. Deposition of Col-I, FN, BSP and OPN+ cementoid and osteoid became evident after 4 weeks. Extrinsic fibres of cementum and bone stained intensely for Col-Ill. The newly formed periodontal ligament expressed FN, Col-I and Col-III, but no BSP or OPN. Conclusions: The spatial ECM expression was similar for OFD and the different GTR methods, although the timing and quantity of ECM expression were influenced by wound stabilization and inflammatory reactions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXPANDED POLYTETRAFLUOROETHYLENE MEMBRANES; AUTOLOGOUS PLATELET CONCENTRATE; HUMAN INTRABONY DEFECTS; BONE SIALOPROTEIN; BEAGLE DOGS; CONNECTIVE-TISSUE; LIGAMENT CELLS; ALVEOLAR BONE; MONOCLONAL-ANTIBODIES; GINGIVAL FIBROBLASTS; bone; bone sialoprotein; cementum; collagen; extracellular matrix; fibronectin; immunohistochemistry; osteopontin; periodontal ligament; periodontitis; regeneration |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 27 Nov 2020 06:32 |
| Last Modified: | 27 Nov 2020 06:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32452 |
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